Endocrine

Epitalon

Synthetic tetrapeptide inspired by pineal gland extracts. Researched in ageing biology, with limited evidence.

Preclinical

Overview

Epitalon (also spelled Epithalon) was developed from studies of epithalamin, a pineal gland extract. Most data come from in vitro, animal and small clinical studies from a single research group, without robust independent replication.

Mechanism of action

Hypotheses include modulation of telomerase activity and melatonin rhythm. Mechanisms not independently confirmed.

Research areas

Ageing biology
Telomeres
Circadian rhythm

Selected references

Khavinson VKh. Peptides and Ageing. Neuro Endocrinol Lett. 2002;23 Suppl 3:11–144. PubMed ↗

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