Tissue repair

BPC-157

Pentadecapeptide derived from a gastric juice protein. Widely studied in animal models; human data are scarce.

Preclinical

Overview

BPC-157 (“Body Protection Compound”) is a partial sequence of a protein isolated from human gastric juice. Most of the literature comes from rodent studies, concentrated in a small number of research groups. Recent reviews stress the need for controlled clinical trials before any conclusion on safety or efficacy in humans.

Mechanism of action

Hypotheses under study include modulation of angiogenesis (via VEGFR2), the nitric oxide system and growth factors. Mechanisms are not yet established.

Research areas

  • Tendon healing (animal models)
  • Gastrointestinal mucosa
  • Angiogenesis

Selected references

  1. Seiwerth S et al. BPC 157 and Standard Angiogenic Growth Factors. Gastrointestinal Tract Healing, Lessons from Tendon, Ligament, Muscle and Bone Healing. Curr Pharm Des. 2018;24(18):1972–1989. PubMed ↗

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